Semaglutide vs Tirzepatide: Which GLP-1 Medication Is Right for You?
GLP-1 medications have transformed the treatment of type 2 diabetes and obesity. Among the most talked-about options today are Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound). If you’re exploring weight loss medications, you’ve likely asked yourself: Semaglutide vs Tirzepatide — which one is better?
In this article, we’ll break down the key differences, similarities, effectiveness, side effects, cost, and help you decide which GLP-1 medication may be the right fit for your weight loss or diabetes journey.
What Are GLP-1 Medications?
GLP-1 (glucagon-like peptide-1) medications mimic the body's natural hormone that helps control blood sugar and appetite. Both Semaglutide and Tirzepatide work by increasing satiety and slowing gastric emptying, which leads to significant weight loss and better glucose regulation.
Comparison Table: Semaglutide vs Tirzepatide
| Feature | Semaglutide (Ozempic/Wegovy) | Tirzepatide (Mounjaro/Zepbound) |
|---|---|---|
| Drug Class | GLP-1 Receptor Agonist | Dual GIP/GLP-1 Receptor Agonist |
| FDA-Approved For | Type 2 Diabetes, Obesity | Type 2 Diabetes, Obesity |
| Average Weight Loss | 14–16% | 20–22% |
| Weekly Injection? | Yes | Yes |
| Onset of Results | 4–8 weeks | 2–4 weeks |
| Most Common Side Effects | Nausea, vomiting, fatigue | Nausea, diarrhea, mild fatigue |
| Insurance Coverage | Often Partial | Often Partial |
| Cost Without Insurance | $900–$1,300/month | $1,000–$1,500/month |
| Available Online? | Yes | Yes |
Which GLP-1 Is More Effective?
Tirzepatide has shown slightly better results in clinical trials. In the SURMOUNT-1 study, participants lost an average of 22.5% of their body weight on the highest dose. Semaglutide participants in similar trials lost about 15%.
That said, individual responses vary — some patients tolerate Semaglutide better or experience fewer side effects.
What About Side Effects?
| Side Effect | Semaglutide | Tirzepatide |
|---|---|---|
| Nausea | Very common | Common (but milder) |
| Diarrhea | Moderate | More frequent |
| Fatigue | Occasionally reported | Occasionally reported |
| Appetite Loss | Common | Stronger appetite suppression |
Both medications may cause GI symptoms, especially in the first few weeks. Starting on a low dose and gradually increasing can help.
Cost and Access Without Insurance
Neither Semaglutide nor Tirzepatide is cheap without insurance. However, many telehealth services (like Vigormeds) offer access to licensed providers who can prescribe these medications with monthly plans starting from $59/month (consult only). Medication costs are billed separately, and generic or compounded options may be available in some states.
How to Decide?
Consider Semaglutide if you:
- Prefer a more established option
- Want a medication FDA-approved specifically for weight loss (Wegovy)
- Respond well to GLP-1s alone
Consider Tirzepatide if you:
- Have more weight to lose
- Want faster or more dramatic results
- Tolerate combination therapies well
Consulting with a licensed provider is the best way to assess which GLP-1 medication is right for you.
